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KMID : 1143120160060030164
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Asia Pacific Allergy
2016 Volume.6 No. 3 p.164 ~ p.167
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The efficacy of single premedication with antihistamines for radiocontrast media hypersensitivity
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Lee So-Hee
Park Heung-Woo
Cho Sang-Heon
Kim Sun-Sin
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Abstract
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Background: Single premedication with antihistamines for radiocontrast media (RCM) hypersensitivity is frequently used in real world at the emergent situation although its efficacy is not proven.
Objective: To evaluate the effect of intravenous antihistamines as a premedication in general population who had experience of mild adverse reactions to iodinated RCM.
Methods: A retrospective observational study on 14,785 subjects who had RCM-enhanced computed tomography scans between January 2014 and December 2015 in Seoul National University Hospital Gangnam Healthcare Center, Seoul, South Korea.
Results: Among 453 subjects who had a history of mild RCM-induced hypersensitivity reactions, 273 subjects had a single premedication of intravenous antihistamine. When comparing antihistamine-premedication group and nonpremedication group, there is no protective effect of antihistamines on the incidence rate and severity of hypersensitivity (10.6% vs. 11.7%, p = 0.729).
Conclusion: The clinical efficacy of a single premedication of antihistamines for mild RCM-induced hypersensitivity was not confirmed.
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KEYWORD
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Radiocontrast media, Hypersensitivity, Premedication
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