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KMID : 1143120160060040220
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Asia Pacific Allergy
2016 Volume.6 No. 4 p.220 ~ p.225
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Pale nasal mucosa affects airflow limitations in upper and lower airways in asthmatic children
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Motomura Chikako
Odajima Hiroshi
Yamada Atsunobu
Taba Naohiko
Murakami Yoko
Nishima Sankei
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Abstract
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Background: Severe asthmatics are thought to have severer rhinitis than mild asthmatics. A pale nasal mucosa is a typical clinical finding in subjects with severe allergic rhinitis.
Objective: The aim of this study was to investigate whether a pale nasal mucosa affects airflow limitations in the upper and lower airways in asthmatic children.
Methods: Rhinomanometry, nasal scraping, and spirometry were performed in 54 asthmatic children (median age, 10 years). The nasal mucosa was evaluated by an otolaryngologist. Thirty-seven patients were treated with inhaled corticosteroids, and 11 patients were treated with intranasal corticosteroids.
Results: Subjects with a pale nasal mucosa (n = 23) exhibited a lower nasal airflow (p < 0.05) and a larger number of nasal eosinophils (p < 0.05) in the upper airway as well as lower pulmonary functional parameters (p < 0.05 for all comparisons), i.e., the forced vital capacity (FVC), the forced expiratory volume in 1 second, and the peak expiratory flow, compared with the subjects who exhibited a normal or pinkish mucosa (n = 31). No significant difference in the forced expiratory flow between 25%?75% of the FVC, regarded as indicating the peripheral airway, was observed between the 2 groups.
Conclusion: A pale nasal mucosa may be a predictor of eosinophil infiltration of the nasal mucosa and central airway limitations in asthmatic children. When allergists observe a pale nasal mucosa in asthmatic children, they should consider the possibility of airflow limitations in not only the upper airway, but also the lower airway.
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KEYWORD
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Rhinitis, allergic, Asthma, Eosinophils, Airflow limitation, Nasal obstruction
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