|
KMID : 1143120160060040236
|
|
Asia Pacific Allergy
2016 Volume.6 No. 4 p.236 ~ p.244
|
|
|
Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis
|
|
Shi Linbo
Zou Li
Gao Jinyan
Xu Huaing
Shi Xiaoyun
Chen Hongbing
|
|
|
Abstract
|
|
|
Background: Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available.
Objective: This study aims to examine the effects of imidacoprid on IgE-mediated mast cell activation.
Methods: The rat basophilic leukemia cell line RBL-2H3 (RBL-2H3 cells) were treated with 10-3 ? 10-12 mol/L imidacloprid, followed by measuring the mediator production, influx of Ca2+ in IgE-activated RBL-2H3 cells, and the possible effects of imidacoprid on anti-dinitrophenyl IgE-induced passive cutaneous anaphylaxis (PCA).
Results: It was shown that imidacoprid suppressed the production of histamine, β-hexosaminidase, leukotriene C4, interleukin-6, tumor necrosis factor-α, and Ca2+ mobilization in IgE-activated RBL-2H3 cells and decreased vascular extravasation in IgE-induced PCA.
Conclusion: It is the first time to show that imidacloprid suppressed the activation of RBL-2H3 cells.
|
|
|
KEYWORD
|
|
|
Imidacloprid, Mast cells, Ca2+ influx
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|