|
KMID : 1143120200100010003
|
|
Asia Pacific Allergy
2020 Volume.10 No. 1 p.3 ~ p.3
|
|
|
Forced oscillation technique as a predictor for loss of control in asthmatic children
|
|
Kreetapirom Piyawut
Kiewngam Potjanee
Jotikasthira Wanlapa
Kamchaisatian Wasu
Benjaponpitak Suwat
Manuyakorn Wiparat
|
|
|
Abstract
|
|
|
Background: A reliable objective tool using as a predictor of asthma control status could assist asthma management.
Objective: To find the parameters of forced oscillation technique (FOT) as predictors for the future loss of asthma symptom control.
Methods: Children with well-controlled asthma symptom, aged 6?12 years, were recruited for a 12-week prospective study. FOT and spirometer measures and their bronchodilator response were evaluated at baseline. The level of asthma symptom control was evaluated according to Global Initiative for Asthma.
Results: Among 68 recruited children, 41 children (60.3%) maintain their asthma control between 2 visits (group C-C), and 27 children (39.7%) lost their asthma control on the follow-up visit (group C-LC). Baseline FOT parameters, including the values of respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), respiratory reactance at 5 Hz, area of reactance, %predicted of R5 and percentage of bronchodilator response (%?) of R5 and R20 were significantly different between C-C and C-LC groups. In contrast, only %? of forced vital capacity, forced expiratory volume in 1 second (FEV1), and FEF25%?75% (forced expiratory flow 25%?75%) were significantly different between groups. Multiple logistic regression analysis revealed that %predicted of R5, %?R5, %predicted of FEV1 and %?FEV1 were the predictive factors for predicting the future loss of asthma control. The following cutoff values demonstrated the best sensitivity and specificity for predicting loss of asthma control: %predicted of R5=91.28, %?R5=21.2, %predicted of FEV1=89.5, and %?FEV1=7.8. The combination of these parameters predicted the risk of loss of asthma control with area under the curve of 0.924, accuracy of 83.8%.
Conclusion: Resistance FOT measures have an additive role to spirometric parameter in predicting future loss of asthma control.
|
|
|
KEYWORD
|
|
|
Resistance, Reactance, Spirometry, Frequency of resonance, Asthma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|