|
KMID : 1143120230130010003
|
|
Asia Pacific Allergy
2023 Volume.13 No. 1 p.3 ~ p.9
|
|
|
Validation of the Chinese drug hypersensitivity quality of life questionnaire: Role of delabeling
|
|
Hugo W.F. Mak
Elsie T.S. Chan
Jackie S.H. Yim
Elaine Lee
Kim Hyang-Kyoung
Valerie Chiang
Philip H. Li
|
|
|
Abstract
|
|
|
Background : The Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q) is not currently available in Chinese. Besides, penicillin allergy (PA) is a worldwide public health challenge, and delabeling inauthentic PA can improve clinical and economic outcomes. However, its effect on health-related quality of life (HRQoL) remains poorly known.
Objective : The study objective is to translate and validate a Chinese version of DrHy-Q and investigate the effect of PA delabeling on HRQoL using DrHy-Q.
Methods : A Chinese DrHy-Q was translated then completed by patients with drug allergy labels for psychometric validation. Afterwards, another cohort of patients finished the Chinese DrHy-Q before and after their PA workup for pre?post comparison.
Results : A total of 130 patients were studied. Sixty-three patients (79.4% female; median age = 59?±?15 years) completed the Chinese DrHy-Q for validation (mean score = 38.9?±?23.5). It demonstrated excellent internal consistency (Cronbach α = 0.956; 95% confidence interval [CI], 0.939?0.971) and test?retest reliability (intraclass correlation coefficient = 0.993 [95% CI, 0.969?0.998]). Construct validity was confirmed by its one-dimensional structure in factor analysis. Divergent validity was established because only 2 (out of 9) SF-36 scales showed weak negative correlations to DrHy-Q. Patients with multiple implicated drugs presented significantly higher DrHy-Q scores than those with only a single drug (42.0?±?22.5 vs 28.7?±?24.4; P = 0.038), showing discriminant validity. Subsequently, another 67 patients (73.1% female; median age = 56?±?15 years) underwent PA investigations and completed their pre?post DrHy-Q. A significant drop in DrHy-Q score was shown (40.8?±?21.7 vs 26.6?±?22.5; Cohen’s d = 0.964; P < 0.001), reflecting improvement in HRQoL.
Conclusion : The Chinese DrHy-Q is reliable and valid for HRQoL assessment. PA delabeling significantly benefits patients’ HRQoL. Future larger-scale studies are warranted to corroborate our findings.
|
|
|
KEYWORD
|
|
|
Delabeling, Drug allergy, Penicillin, Quality of life, Questionnaire, Validation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|