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KMID : 1143420200130483420
Public Health Weekly Report
2020 Volume.13 No. 48 p.3420 ~ p.3429
Korea 2019-2020 Influenza Laboratory Surveillance Report and Recommendations for the 2020-2021 Influenza Vaccine Strains in the Northern Hemisphere
Kim Heui-Man

Lee Nam-Joo
Kim Eun-Jin
Abstract
Influenza and Respiratory Viruses Surveillance System (KINRESS) has been in place to strengthen the monitoring of the prevalence patterns of influenza and respiratory viruses in South Korea. From September 1, 2019 to August 30, 2020, respiratory specimens (i.e., throat or nasal swabs) were collected from 52 private clinics in the Republic of Korea (ROK) from patients with influenza-like illnesses and acute respiratory tract infections. Subsequently, multiplex real-time RT-PCR was performed to detect influenza viruses (A, B, A(H1N1)pdm09, A(H3N2), B-Victoria lineage, and B-Yamagata lineage) at 18 Public Health and Environment Research Institutes (PHERIs). Among the real-time RT-PCR positive specimens, 10% of the specimens were randomly selected and cultured for virus isolation. Hemagglutination Inhibition Assay (HIA) or Focus Reduction Assay (FRA) was used to perform antigenic characterisations of the viruses and NA (Neuraminidase) genetic analysis was used to monitor antiviral drug-resistant viruses. During the flu 2019?2020 season, 8,640 specimens were collected and diagnosed by multiplex real time RT-PCR. Findings indicated that 1,171 (13.6%) cases were positive for influenza. Of these positive cases, 1,122 (95.8%) and 49 (4.2%) cases were confirmed to be influenza A viruses and influenza B viruses, respectively. Of the influenza A viruses, A(H1N1)pdm09 was detected in 825 (70.4%) cases and A(H3N2) was detected in 297 (25.4%) cases. A(H1N1)pdm09 isolates were similar with A/Brisbane/02/2018 genetically and antigenically. However, A(H3N2) and B(Victoria) isolates were distinct from the vaccine strains both genetically as well as antigenically. All isolated influenza viruses were susceptible to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor and resistant to ion channel blockers. The recommended influenza vaccine strains for the 2020-2021 season in the northern hemisphere were A/Guangdong-Maonan/SWL1536/2019 (cell) and A/Hawaii/70/2019 for A(H1N1)pdm09, A/Hong Kong/2671/2019 for A(H3N2), B/Washington/02/2019 for B(Victoria) and B/Phuket/3073/2013 for B(Yamagata) respectively. The updated vaccine strains in 2020-2021 flu season have similar genetic and antigenic characteristics to Korea isolates in 2019-2020 flu season. However, due to frequent mutations in influenza viruses it will be necessary to continuously monitor characterisation of influenza in the 2020-2021 flu season through KINRESS.
KEYWORD
Influenza, Influenza virus, Surveillance, 2019-2020 flu season
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