KMID : 1143520210090040040
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Journal of Korean Society of Oral Health Science 2021 Volume.9 No. 4 p.40 ~ p.46
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Efficacy of Combined Administration of Cinnamon and Curcumin on Acute Orofacial Inflammatory Pain Enhanced by Xerostomia
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Choi Ja-Hyeong
Nam Seoul-Hee Lee Min-Kyung
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Abstract
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Objectives: Orofacial pain can be caused by xerostomia, dental procedures, infections, and functional disorders in various areas, and it can greatly deteriorate patients¡¯ quality of life. Thus, the present study aimed to investigate the efficacy of natural products in minimizing the side effects of synthetic drugs.
Methods: In an experimental model of 4-DAMP-induced xerostomia, formalin was injected to induce inflammatory pain in the orofacial region, and the effects of oral administration of curcumin and cinnamon on pain behavioral response were observed.
Results: In the experimental group with xerostomia, the pain response was prominent, which was suppressed in a concentration-dependent manner upon curcumin and cinnamon administration.
Conclusions: Curcumin and cinnamon may be useful natural products for relieving the inflammatory orofacial pain caused by xerostomia.
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KEYWORD
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Cinnamon, Curcumin, Natural products, Orofacial pain, Xerostomia
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