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KMID : 1146420120040010029
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Korean Medical Association of Clinical Sanghan-Geumgwe
2012 Volume.4 No. 1 p.29 ~ p.36
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Effect of the Gardenia jsaminodes and Glycine max on Hepatotoxicity of D-Galactosamine in Rats
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Kim Jeong-Sang
Jeong Jong-Gil
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Abstract
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Aim : To investigate the hepatotective effect of Gardenia jsaminodes and Glycine max aqueous extract against D-galactosamine (d-GalN, 300mg/kg body weight) was administered to the male Sprague Dawley (SD) rats. Materials and
Methods : The study was carried out on male SD rats (age matched, weight 2500±10g). Experimental groups divided four: Normal group (Nor) was administered saline, Control (Con) group was administered saline after d-GalN treatment. Experimental group (Exp) was administered Gardenia jsaminodes (200 mg/kg; Ga group), Glycine max (700 mg/kg; Gl group), and Gardenia jsaminodes+Glycine max (200 mg/kg+700 mg/kg, GG group) during 14 days(n=5).
Results : d-GalN administration induced hepatotoxicity in rats which was manifested by increased levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase but decreased total cholesterol and triglyceride. Treatment with Gardenia jsaminodes extract significantly protected the liver in d-GalN administered rats.
Conclusion : Gardenia jsaminodes aqueous extract and Gardenia jsaminodes+Glycine max extract possesses hepatoprotective potential, thus validating its use in alleviating toxic effects of d-GalN.
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KEYWORD
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D-galactosamine , Gardenia jsaminodes , Glycine max , hepatotective
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