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KMID : 1146920180480010043
Journal of Pharmaceutical Investigation
2018 Volume.48 No. 1 p.43 ~ p.60
Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics
Choi Young-Hee

Han Hyo-Kyung
Abstract
Nanomedicines have evolved into various forms including dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles since their first launch in the market. Widely highlighted benefits of nanomedicines over conventional medicines include superior efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profiles of pharmaceutical ingredients. Especially, various kinetic characteristics of nanomedicines in body are further influenced by their formulations. This review provides an updated understanding of nanomedicines with respect to delivery and pharmacokinetics. It describes the process and advantages of the nanomedicines approved by FDA and EMA. New FDA and EMA guidelines will also be discussed. Based on the analysis of recent guidelines and approved nanomedicines, key issues in the future development of nanomedicines will be addressed.
KEYWORD
Nanomedicines, Pharmacokinetics, Delivery, Guidelines
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