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KMID : 1147220210220030135
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Journal of Biomedical and Translational Research
2021 Volume.22 No. 3 p.135 ~ p.139
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Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis
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Yeo Hyeon-Gu
Park Jung-Hyung
Kim Hyun-Kuk
Lee Joo-Myung
Koo Bon-Sang
An Jeong-Hee
Jeon Chang-Yeop
An You-Jung
Choi Won-Seok
Park Sung-Hyun
Seo Jin-Cheol
Won Jin-Young
Kim Keon-Woo
Cho Ji-Yeon
Kim Yu-Gyeong
Kim Min-Ji
Seong Jung-Bae
Huh Jae-Won
Kim Sung-Soo
Lee Young-Jeon
Lim Kyung-Seob
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Abstract
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Naturally occurring left ventricular hyperplasia is a rare but lethal disease. There are very few reports of this cardiac disease in captive nonhuman primates. In a colony of Macaca mulatta (Rhesus monkey) at California National Primate Research Center, a large number of rhesus macaques were diagnosed by autopsy with naturally occurring left ventricular hypertrophy without obvious underlying diseases over a 22-year period. The confirmatory diagnosis of ventricular hypertrophy was based on findings of notable left ventricular concentric hypertrophy with reduced left ventricular lumen, which is very similar to human ventricular hypertrophy cases. This report discusses an 11-year-old Macaca fascicularis monkey (Cynomolgus monkey, crab-eating macaque), weighing 2.95 kg, that was presented for enrollment in a pharmacokinetic (PK) study. During the PK experiment, the monkey died following a sudden decrease in percutaneous oxygen saturation and heart rate. Gross and histological examinations of the heart were performed. On gross pathology, the left ventricular wall was thickened, and the chamber lumen was reduced. In histopathological examination using hematoxylin-eosin and Masson-trichrome stains, fibrosis and myocyte disarray were not observed, but an increased cell density, compared to the normal heart, was confirmed. The autopsy results confirmed left ventricular hyperplasia as the major cause of death.
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KEYWORD
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non-human primate, autopsy, hypertrophy, left ventricular, sudden cardiac death, pathology
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