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KMID : 1148920060400060279
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Nuclear Medicine and Molecular Imaging
2006 Volume.40 No. 6 p.279 ~ p.292
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Translational Imaging with PET Reporter Gene Approaches
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Min Jung-Joon
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Abstract
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Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of biomedical research. These tools have been validated recently in variety of research models, and have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of PET technologies as they have been used in imaging biological processes for molecular imaging applications. The studies published to date demonstrate that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases. (Nucl Med Mol Imaging 2006;40(6):279-292)
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KEYWORD
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molecular imaging, positron emission tomography, gene expression, cell trafficking, gene therapy
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