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KMID : 1148920070410020132
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Nuclear Medicine and Molecular Imaging
2007 Volume.41 No. 2 p.132 ~ p.140
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Imaging of Dopaminergic System in Movement Disorders
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Kim Yu-Kyeong
Kim Sang-Eun
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Abstract
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Parkinson’s disease is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several radiopharmaceutics have been developed to evaluate the integrity of dopaminergic neuronal system. In vivo PET and SPECT imaging of presynaptic dopamine imaing are already applied to Parkinson’s disease and other parkinsonism, and can demonstrate the dopaminergic dysfunction. This review summarized the use of the presynaptic dopaminergic imaging in PD as biomarkers in evaluation of disease progression as well as in diagnosis of PD.
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KEYWORD
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Parkinson’s disease, dopaminergic system, biomarker
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