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KMID : 1148920070410030194
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Nuclear Medicine and Molecular Imaging
2007 Volume.41 No. 3 p.194 ~ p.200
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Correlation between Semiquantitative Myocardial Perfusion Score and Absolute Myocardial Blood Flow in 13N-Ammonia PET
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Lee Byeong-Il
Kim Kye-Hun
Min Jung-Joon
Song Ho-Chun
Bom Hee-Seung
Kim Su-Jin
Lee Jae-Sung
Kim Jung-Young
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Abstract
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Purpose: 13N-ammonia is a well known radiopharmaceutical for the measurement of a myocardial blood flow (MBF) non-invasively using PET-CT. In this study, we investigated a correlation between MBF obtained from dynamic imaging and myocardial perfusion score (MPS) obtained from static imaging for usefulness of cardiac PET study.
Methods: Twelve patients (11 males, 1 female, 57.9±8.6 years old) with suspicious coronary artery disease underwent PET-CT scan. Dynamic scans (6 min: 5 sec X 12, 10 sec X 6, 20 sec X 3, and 30 sec X 6) were initiated simultaneously with bolus injection of 11 MBq/kg 13N-ammonia to acquire rest and stress image. Gating image was acquired during 13 minutes continuously. Nine-segment model (4 basal walls, 4 mid walls, and apex) was used for a measurement of MBF. Time activity curve of input function and myocardium was extracted from ROI methods in 9 regions for quantification. The MPS were evaluated using quantitative analysis software. To compare between 20-segment model and 9-segment model, 6 basal segments were excluded and averaged segmental scores were used.
Results: There are weak correlation between MBF (rest, 0.18-2.38 ml/min/g; stress, 0.40-4.95 ml/min/g) and MPS (rest 22-91%, stress, 14-90%), however the correlation coefficient between corrected MBF and MPS in rest state was higher than stress state (rest r=0.59; stress r=0.80). As a thickening increased, correlation between MBF and MPS also showed good correlation at each segments.
Conclusions: Corrected and translated MPS as its characteristics using 13N-ammonia showed good correlation with absolute MBF measured by dynamic image in this study. Therefore, we showed MPS is one of good indices which reflect MBF. We anticipate PET-CT could be used as useful tool for evaluation of myocardial function in nuclear cardiac study. (Nucl Med Mol Imaging 2007;41(3):194-200)
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KEYWORD
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myocardial blood flow, perfusion, cardiac PET, 13N-ammonia
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