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KMID : 1148920070410060538
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Nuclear Medicine and Molecular Imaging
2007 Volume.41 No. 6 p.538 ~ p.545
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Correlation of Pre-treatment FDG Uptake to Therapeutic Response and Relapse in Patients with Small Cell Lung Cancer
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Seo Young-Soon
Kim Kyu-Sik
Kim Young-Chul
Min Jung-Joon
Song Ho-Chun
Bom Hee-Seung
Kwon Seong-Young
Jeong Shin-Young
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Abstract
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Purpose : We evaluated correlation of 18F-FDG uptakes, therapeutic response and relapse in pre-treatment 18F-FDG PET/CT in patients with SCLC.
Materials and methods: We included 26 patients with pathologically proven small cell lung cancer. Total 102 lesions (26 lungs, 69 lymph nodes and 8 metastatic lesions) were evaluated. All patients underwent 18F-FDG PET/CT for staging. The maxSUV was used as a parameter of 18F-FDG uptake. The patients were divided into responders and non-responders according to response criteria on chest CT scan after 3 cycles of chemotherapy. We compared maxSUV between two groups by using independent t-test. To access correlation with 18F-FDG uptake and relapse, maxSUV and interval time to relapse was analyzed by correlation analysis. The cutoff value of maxSUV was evaluated by ROC curve.
Results: Twelve-one patients (81%) were responders and five patients were non-responders on follow-up chest CT scan. The mean maxSUV of main lung lesions in responders and non-responders were 14.15±3.72 and 9.17±2.15, respectively. The maxSUV in the responders was significantly lower than that in non-responders ( p<0.05). According to ROC curve, point of cut that predicts therapeutic response was 8.98 with 100% sensitivity and 57% specificity. The correlation analysis between 18F-FDG uptakes and interval time to relapse showed a significant negative correlation ( p<0.05, r=-0.757).
Conclusion: The pre-treatment 18F-FDG uptake of responders was significantly lower than that of non-responders. Patients with high 18F-FDG uptake in pre-treatment 18F-FDG PET/CT relapse earlier. (Nucl Med Mol Imaging 2007;41(6):538-545)
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KEYWORD
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small cell lung cancer, 18F-FDG PET/CT
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