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KMID : 1148920070410060566
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Nuclear Medicine and Molecular Imaging
2007 Volume.41 No. 6 p.566 ~ p.569
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Quality Control of Residual Solvents in [18F]FDG Preparations by Gas Chromatography
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Lee Hak-Jeong
Jeong Jae-Min
Lee Yoon-Sang
Kim Hyung-Woo
Chang Young-Soo
Lee Dong-Soo
Chung June-Key
Lee Myung-Chul
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Abstract
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Purpose: Analysis of volatile organic solvents in 2-deoxy-2-[18F] fluoro-D-glucose ([18F]FDG) preparations was performed by gas chromatography (GC), in accordance with USP.
Material and Methods : Analyses were carried out on a Hewlett-Packard 6890 gas chromatography equipped with an FID.
Results: We determined the amounts of ethanol and acetonitrile on every batch of our routine [18F]FDG preparations, ranging between 5000 ppm and 100 ppm. In our routine preparation of [18F]FDG, the amount of acetonitrile and ethanol in the final product were well below the maximum allowable limit described in the USP.
Conclusion: Our [18F]FDG preparations were in accordance with the suggested USP maximum allowable levels of the quality control analysis of volatile organic compounds. (Nucl Med Mol Imaging 2007;41(6):566-569)
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KEYWORD
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residual solvents, [18F]FDG, gas chromatography, quality control
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