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KMID : 1148920080420020145
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Nuclear Medicine and Molecular Imaging
2008 Volume.42 No. 2 p.145 ~ p.152
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Quantitation of In-Vivo Physiological Function using Nuclear Medicine Imaging and Tracer Kinetic Analysis Methods
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Kim Su-Jin
Lee Jae-Sung
Kim Kyeong-Min
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Abstract
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Nuclear medicine imaging has an unique advantage of absolute quantitation of radioactivity concentration in body. Tracer kinetic analysis has been known as an useful investigation methods in quantitative study of in-vivo physiological function. The use of nuclear medicine imaging and kinetic analysis together can provide more useful and powerful intuition in understanding biochemical and molecular phenomena in body. There have been many development and improvement in kinetic analysis methodologies, but the conventional basic concept of kinetic analysis is still essential and required for further advanced study using new radiopharmaceuticals and hybrid molecular imaging techniques. In this paper, the basic theory of kinetic analysis and imaging techniques for suppressing noise were summarized.
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KEYWORD
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nuclear medicine imaging, tracer kinetic modeling, PET, SPECT
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