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KMID : 1148920100440040233
Nuclear Medicine and Molecular Imaging
2010 Volume.44 No. 4 p.233 ~ p.240
68Ga-Labeled Radiopharmaceuticals for Positron Emission Tomography
Shetty Dinesh

Lee Yun-Sang
Jeong Jae-Min
Abstract
68Ga is a promising emerging radionuclide for positron emission tomography (PET). It is produced using a 68Ge/68Ga-generator, and thus, would enable the cyclotron-independent distribution of PET. However, new 68Ga-labeled radiopharmaceuticals that can replace 18F-labeled agents like [18F]fluorodeoxyglucose (FDG) are needed. Most of the 68Ga-labeled derivatives currently used are peptide agents, but the developments of other agents, such as amino acid derivatives, nitroimidazole derivatives, and glycosylated human serum albumin, are being actively pursued in many laboratories. Thus, appearance of new 68Ga-labeled radiopharmaceuticals with high impact are expected in the near future. Here, we present an overview of 68Ga-labeled agents in terms of their clinical significances and relevances to the management of certain tumors, and pertinent pre-clinical developments.
KEYWORD
Gallium-68, PET, Peptide, DOTA, NOTA, BAPEN, MSA, Ga-68
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