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KMID : 1148920100440040261
Nuclear Medicine and Molecular Imaging
2010 Volume.44 No. 4 p.261 ~ p.266
Imaging Atherosclerosis in the Carotid Arteries with F-18-Fluoro-2-deoxy-D-glucose Positron Emission Tomography: Effect of Imaging Time after Injection on Quantitative Measurement
Oh Min-Young

Kim Ji-Young
Shin Kwang-Ho
Park Seol-Hoon
Ryu Jin-Sook
Kim Jae-Seung
Kim Hye-Jin
Kang Dong-Wha
Moon Dae-Hyuk
Abstract
Purpose: To compare F-18-fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) imaging at two different circulation times after injection of F-18 FDG in order to measure atherosclerosis in carotid arteries.

Methods: We assessed 12 patients with recent symptomatic plaques in the carotid arteries. F-18 FDG PET/CT carotid plaque imaging was performed for 20 min at 2 h after F-18 FDG injection in five patients and at 3 h in seven patients. We measured vessel wall uptake using the maximal standardized uptake value (SUV), and the mean and maximal blood target-to-background ratios (TBR) of the symptomatic carotid arteries. Blood pool activity (BPA) was measured as the mean SUV of the superior vena cava (SVC) and jugular vein of these 12 patients, and in 14 age- and gender-matched patients who underwent whole-body F-18 FDG PET/CT examinations 1 h after injection.

Results: F-18 FDG PET/CT revealed visible F-18 FDG uptake in all patients with symptomatic carotid plaques. Maximal SUV did not differ between groups evaluated at 2 h and 3 h (2.62?¡¾?0.45 vs 3.00?¡¾?0.85, p?=?0.335). However, mean (2.04?¡¾?0.22 vs 3.54?¡¾?0.62, p?
Conclusions: Symptomatic carotid plaques are visualized for a relatively short period of imaging time on ¡Ã1-h PET/CT images. Quantitative parameters of atherosclerotic carotid arteries are preserved or even increased over time, whereas those of blood pools are decreased.
KEYWORD
F-18 FDG PET/CT, Atherosclerosis, Carotid arteries, Imaging time
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