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KMID : 1148920110450030002
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Nuclear Medicine and Molecular Imaging
2011 Volume.45 No. 3 p.2 ~ p.2
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Using 18F-FDG PET/CT to Detect an Occult Mesenchymal Tumor Causing Oncogenic Osteomalacia
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Seo Hyo-Jung
Choi Yun-Jung
Kim Hyun-Jeong
Jeong Yong-Hyu
Cho Arthur
Lee Jae-Hoon
Yun Mi-Jin
Lee Jong-Doo
Kang Won-Jun
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Abstract
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Oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by renal phosphate excretion, hypophosphatemia, and osteomalacia. This syndrome is often caused by tumors of mesenchymal origin. Patients with oncogenic osteomalacia have abnormal bone mineralization, resulting in a high frequency of fractures. Tumor resection is the treatment of choice, as it will often correct the metabolic imbalance. Although oncogenic osteomalacia is a potentially curable disease, diagnosis is difficult and often delayed because of the small size and sporadic location of the tumor. Bone scintigraphy and radiography best characterize osteomalacia; magnetic resonance imaging findings are nonspecific. Here, we report a case of oncogenic osteomalacia secondary to a phosphaturic mesenchymal tumor that was successfully detected by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). This case illustrates the advantages of 18F-FDG PET/CT in detecting the occult mesenchymal tumor that causes oncogenic osteomalacia.
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KEYWORD
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Oncogenic osteomalacia, 18F-fluorodeoxyglucose, Positron emission tomography
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