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KMID : 1148920110450030005
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Nuclear Medicine and Molecular Imaging
2011 Volume.45 No. 3 p.5 ~ p.5
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Clinical Significance of Diffuse 18F-FDG Uptake in Residual Thyroid Gland after Unilateral Thyroid Lobectomy
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Song Hee-Sung
Lee Su-Jin
Yoon Seok-Ho
Lee Jan-Dee
Soh Euy-Young
An Young-Sil
Yoon Joon-Kee
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Abstract
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Purpose: We investigated the clinical significance of diffuse uptake in remaining thyroid after unilateral lobectomy for thyroid cancer.
Methods: A total of 144 thyroid cancer patients who underwent 18F-FDG PET/CT after lobectomy were enrolled in the present study. The PET/CT images were evaluated for the presence of diffuse 18F-FDG uptake with maximum SUV (SUVmax) >2.0 in the residual thyroid and placed into one of two groups: with diffuse uptake and without diffuse uptake group. Clinical, laboratory, and PET/CT parameters in both groups were compared. Correlations between SUVmax of thyroid and available parameters were analyzed.
Results: Forty-two of 144 patients (29.2%) had diffuse thyroid uptake (mean SUVmax: 3.2?±?1.1). All patients with diffuse uptake and 96 (94.1%) without diffuse uptake were receiving thyroxine therapy (P?=?0.09). Thyroid function tests showed that most patients were euthyroid status (78.6 vs. 85.3%, P?=?0.36). TgAb levels were significantly higher in patients with diffuse uptake (338.0?±?664.6 vs. 57.3?±?46.4, P?
Conclusion: In this study, diffuse 18F-FDG uptake in the residual thyroid after unilateral lobectomy was a relatively frequent finding and may be associated with chronic thyroiditis. This uptake is not influenced by thyroid status or thyroxine therapy. The 18F-FDG uptake is inversely correlated with mean attenuation value of thyroid.
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KEYWORD
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Diffuse thyroid uptake, FDG PET/CT, Thyroiditis, Thyroid lobectomy
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