KMID : 1148920110450030007
|
|
Nuclear Medicine and Molecular Imaging 2011 Volume.45 No. 3 p.7 ~ p.7
|
|
Evaluation of Salivary Gland Dysfunction Using Salivary Gland Scintigraphy in Sjogren¡¯s Syndrome Patients and in Thyroid Cancer Patients after Radioactive Iodine Therapy
|
|
Kang Ji-Yeon
Jang Su-Jin Lee Won-Woo Jang Sung-June Lee Yun-Jong Kim Sang-Eun
|
|
Abstract
|
|
|
Purpose: Salivary gland scintigraphy (SGS) provides an objective means of diagnosing salivary gland dysfunction in Sjogren¡¯s syndrome (SS) patients and in thyroid cancer patients after radioactive iodine (RAI) therapy. In the present study, SGS was performed in SS patients and in thyroid cancer patients post-RAI, and scintigraphic parameters were compared.
Methods: Twenty-eight SS patients (males:females?=?1:27, age 53.3?¡¾?11.9 years), 28 controls (males:females?=?3:25, age 54.1?¡¾?10.1 years), and 92 thyroid cancer patients (males:females?=?28:64, age 46.2?¡¾?12.9) who had undergone a session of high-dose RAI therapy (mean dose, 5.2?¡¾?1.5 GBq) were included. SGS was performed using Tc-99m pertechnetate (925 MBq). Scintigraphic parameters (parotid uptake ratio PU, submandibular uptake ratio SU, percentage parotid excretion %PE, and percentage submandibular excretion %SE) were measured and compared for SS, thyroid cancer post-RAI, and control patients.
Results: PU, SU, %SE, and %PE were all significantly lower in SS than in post-RAI thyroid cancer or control patients (p?0.05), whereas only %PE was significantly lower in post-RAI thyroid cancer patients than in controls (p?0.05). SU and %SE were found to be correlated with the unstimulated whole salivary flow rate.
Conclusion: Scintigraphic parameters derived from SGS can play a crucial role in the detection of salivary gland dysfunction in SS patients and in post-RAI thyroid cancer patients.
|
|
KEYWORD
|
|
Salivary gland scintigraphy, Sjogren¡¯s syndrome, Radioactive iodine therapy, Thyroid cancer, Tc-99m pertechnetate
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|