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KMID : 1148920110450040276
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Nuclear Medicine and Molecular Imaging
2011 Volume.45 No. 4 p.276 ~ p.284
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Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism
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Cheon Mi-Ju
Choi Joon-Young
Chung Jae-Hoon
Lee Ji-Young
Cho Sook-Kyung
Yoo Jang
Park Soo-Bin
Lee Kyung-Han
Kim Byung-Tae
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Abstract
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Purpose: This study aimed to investigate the differential findings in clinical and biochemical features, and Tc-99m sestamibi (MIBI) dual-phase parathyroid scintigraphy for malignant and benign parathyroid lesions in patients with primary hyperparathyroidism.
Methods: Subjects were 102 parathyroid lesions from 91 patients with primary hyperparathyroidism. Scintigraphic findings included radioactivity grade, uptake pattern, uptake contour, lesion size on early and delayed images, and degree of washout. Clinical and biochemical features were also evaluated. Histopathology confirmed the final diagnosis for all the patients.
Results: Final diagnoses were 94 benign parathyroid lesions and 8 parathyroid carcinomas. The patients with parathyroid carcinoma were significantly older (p?=?0.002) and had significantly higher serum parathyroid hormone concentrations than those with benign parathyroid lesions (p?
Conclusion: For Tc-99m MIBI dual-phase parathyroid scintigraphy, uptake grade on delayed images and washout were significantly useful diagnostic criteria for differentiating benign from malignant parathyroid lesions, along with age and parathyroid hormone serum concentration.
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KEYWORD
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Primary hyperparathyroidism, Parathyroid carcinoma, Parathyroid adenoma, Parathyroid hyperplasia, Tc-99m Sestamibi, Parathyroid scintigraphy
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