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KMID : 1148920110450040285
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Nuclear Medicine and Molecular Imaging
2011 Volume.45 No. 4 p.285 ~ p.290
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Significance of SUV on Follow-up F-18 FDG PET at the Anastomotic Site of Gastroduodenostomy after Distal Subtotal Gastrectomy in Patients with Gastric Cancer
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Choi Byung-Wook
Zeon Seok-Kil
Kim Sung-Hun
Jo Il
Kim Hae-Won
Won Kyoung-Sook
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Abstract
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Purpose: The aim of this study was to characterize the patterns of fluorodeoxyglucose (FDG) uptake on F-18 FDG positron emission tomography/computed tomography (FDG PET/CT) at the anastomotic site of gastroduodenostomy after distal subtotal gastrectomy in patients with gastric cancer.
Methods: From May 2007 to May 2010, two or more follow-up measurements using FDG PET/CT scans were done for 19 patients (11 men, 8 women; mean age, 62.0?±?10.3 years) who underwent distal subtotal gastrectomy with gastroduodenostomy between February 2006 and March 2008 for detecting gastric cancer recurrence at our medical center. The FDG PET/CT images were retrospectively reviewed. Patients with local recurrence, regional nodal metastasis or distant metastasis on follow-up studies were excluded. CT and endoscopy were done within 1 month before or after the FDG PET/CT scan. Eight patients had two follow-ups of FDG PET/CT, and 11 patients had three follow-ups. The mean interval between surgery and the first follow-up FDG PET/CT was 12.9?±?0.8 months (n?=?19); between the first and second it was 12.3?±?1.0 months (n?=?19); between the second and third it was 11.6?±?0.7 months (n?=?11). The F-18 FDG uptakes at the anastomotic site and fundus in the remnant stomach were measured by maximum standardized uptake value (SUVmax) using a region of interest technique.
Results: The SUVmax at the anastomotic site was significantly higher than that of the fundus on all series of first, second and third follow-up studies (3.3?±?1.1 vs. 2.1?±?0.7, p?
Conclusion: The SUVmax at the anastomotic site is significantly higher than that of the fundus and does not decrease significantly over time. Therefore, the local recurrence of gastric cancer after surgery could not be definitely differentiated from physiologic uptake or postoperative inflammatory change.
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KEYWORD
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F-18 fluorodeoxyglucose, PET, Stomach cancer, Billroth I, Gastroduodenostomy, Anastomotic site
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