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KMID : 1148920110450040291
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Nuclear Medicine and Molecular Imaging
2011 Volume.45 No. 4 p.291 ~ p.298
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18F-FDG Uptake of Human Testis on PET/CT: Correlation with Age, Sex Hormones, and Vasectomy
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Moon Seung-Hwan
Eo Jae-Sun
Lee Jong-Jin
Chung June-Key
Lee Dong-Soo
Lee Myung-Chul
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Abstract
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Purpose: The purpose of this study was to evaluate glucose metabolism of normal human testis on 18F-FDG PET/CT and to assess possible correlations among age, the serum levels of sex hormones, and vasectomy.
Methods: 18F-FDG PET/CT was performed in 66 normal healthy men (50.8?±?13.6 years, range 22?81), and mean standard uptake values (SUV) of 18F-FDG in testis and adductor muscle were measured. Testis-muscle SUV ratios (T/M ratios) were calculated. Serum levels of total testosterone, free testosterone, estradiol, and of sex-hormone binding globulin (SHBG) were measured. We searched for correlations between T/M ratios and age and the serum concentrations of sex hormones. 18F-FDG PET/CT was also performed in 32 vasectomized men (55.7?±?7.8 years, range 38?71) and 52 nonvasectomized men (55.4?±?11.6 years, range 37?72). Mean SUVs of testis and adductor muscle were measured, and T/M ratios were calculated.
Results: A significant age-related decline was found in T/M ratio (r?=??0.509, p?
Conclusions: Glucose metabolism in the testis in an adult population was found to be correlated with age, serum sex hormone level, and vasectomy history. These results indicate that testicular 18F-FDG uptake may have attributed to testicular function and testicular histology. Our findings may have important implications for the interpretation of testicular 18F-FDG uptake in the normal adult population.
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KEYWORD
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18F-FDG PET/CT, Testis, Glucose metabolism, SUV, Testosterone, Vasectomy
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