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KMID : 1148920120460040286
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Nuclear Medicine and Molecular Imaging
2012 Volume.46 No. 4 p.286 ~ p.293
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Metabolic Tumor Volume Measured by F-18 FDG PET/CT can Further Stratify the Prognosis of Patients with Stage IV Non-Small Cell Lung Cancer
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Yoo Su-Woong
Kim Ja-Hae
Chong A-Ri
Kwon Seong-Young
Min Jung-Joon
Song Ho-Chun
Bom Hee-Seung
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Abstract
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Purpose: This study aimed to further stratify prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT).
Materials and Methods: The subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F-18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were measured by receiver operating characteristic (ROC) curve analysis. Kaplan-Meier survival curves were used for evaluation of progression-free survival (PFS). The univariate and multivariate Cox proportional hazards models were used to select the significant prognostic factors.
Results: Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV-lung and TLG-lung) were significant factors for prediction of PFS (P?
Conclusion: Patients with stage IV NSCLC could be further stratified into subgroups of significantly better and worse prognosis by MTV of primary lung lesion.
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KEYWORD
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Metabolic tumor volume, Stage IV non-small cell lung cancer, F-18 FDG PET/CT, Progression-free survival
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