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KMID : 1148920130470030151
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Nuclear Medicine and Molecular Imaging
2013 Volume.47 No. 3 p.151 ~ p.157
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Prognostic Value of Normal Perfusion but Impaired Left Ventricular Function in the Diabetic Heart on Quantitative Gated Myocardial Perfusion SPECT
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Jeong Hwan-Jeong
Lee Dong-Soo
Lee Ho-Young
Choi Se-Hun
Han Yeon-Hee
Chung June-Key
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Abstract
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Purpose: This study aimed at identifying the predictive parameters on quantitative gated myocardial perfusion single-photon emission computed tomography (QG-SPECT) in diabetic patients with normal perfusion but impaired function.
Methods: Among the 533 consecutive diabetic patients, 379 patients with normal perfusion on rest Tl-201/dipyridamole-stress Tc-99m sestamibi Gated SPECT were enrolled. Patients were grouped into those with normal post-stress left ventricular function (Group I) and those with impaired function (EF <50 or impaired regional wall motion, Group II). We investigated cardiac events and cause of death by chart review and telephone interview. Survival analysis and Cox proportional hazard model analysis were performed.
Results: Between the Group I and II, cardiac events as well as chest pain symptoms, smoking, diabetic complications were significantly different (P?
Conclusion: The functional parameter, especially summed systolic thickening score on QG-SPECT had prognostic values, despite normal perfusion, in predicting cardiac events in diabetic patients, and QG-SPECT provides clinically useful risk stratification in diabetic patients with normal perfusion.
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KEYWORD
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Gated myocardial SPECT (Gated SPECT), Diabetes mellitus, Summed systolic thickening score, Prognostic value
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