|
KMID : 1148920130470030173
|
|
Nuclear Medicine and Molecular Imaging
2013 Volume.47 No. 3 p.173 ~ p.180
|
|
|
Dynamic 18 F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts
|
|
Kristian Alexandr
Nilsen Line B.
Roe Kathrine
Revheim Mona Elisabeth
Engebraten Olav
Maelandsmo Gunhild M.
Holm Ruth
Malinen Eirik
Seierstad Therese
|
|
|
Abstract
|
|
|
Purpose: To compare dynamic 2-deoxy-2-[18 F]fluoro-D-glucose positron emission tomography (18?F-FDG PET) parameters in two selected human breast cancer xenografts and to evaluate associations with immunohistochemistry and histology.
Procedures: Dynamic 18?F-FDG PET of luminal-like MAS98.06 and basal-like MAS98.12 xenografts was performed, and the compartmental transfer rates (k1,k2,k3), blood volume fraction (vB) and metabolic rate of 18?F-FDG(MRFDG) were estimated from pharmacokinetic model analysis. After sacrifice, analyses of hypoxia (pimonidazole), proliferation (Ki-67), vascularization (CD31), glucose transport receptor (GLUT1) and necrosis (HE) was performed. The level of hexokinase 2 (HK2) was estimated from Western blot analysis.
Results: The 18?F-FDG uptake curves for the two xenografts were significantly different (p?
Conclusions: Significant differences in dynamic 18?F-FDG parameters between the two human breast cancer xenografts were found. The differences could be explained by underlying histological and physiological characteristics.
|
|
|
KEYWORD
|
|
|
Dynamic 18 F-FDG PET, Kinetic analysis, Breast carcinoma, GLUT1, Ki-67, Perfusion
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|