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KMID : 1148920140480010001
Nuclear Medicine and Molecular Imaging
2014 Volume.48 No. 1 p.1 ~ p.15
Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology
Rahim Muhammad Kashif

Kim Sung-Eun
So Hyeong-Ryul
Kim Hyung-Jun
Cheon Gi-Jeong
Lee Eun-Seong
Kang Keon-Wook
Lee Dong-Soo
Abstract
Image quantification studies in positron emission tomography/computed tomography (PET/CT) are of immense importance in the diagnosis and follow-up of variety of cancers. In this review we have described the current image quantification methodologies employed in 18F-fluorodeoxyglucose (18F-FDG) PET in major oncological conditions with particular emphasis on tumor heterogeneity studies. We have described various quantitative parameters being used in PET image analysis. The main contemporary methodology is to measure tumor metabolic activity; however, analysis of other image-related parameters is also increasing. Primarily, we have identified the existing role of tumor heterogeneity studies in major cancers using 18F-FDG PET. We have also described some newer radiopharmaceuticals other than 18F-FDG being studied/used in the management of these cancers. Tumor heterogeneity studies are being performed in almost all major oncological conditions using 18F-FDG PET. The role of these studies is very promising in the management of these conditions.
KEYWORD
Positron emission tomography, Quantification, Standard uptake value, Tumor heterogeneity studies, Textural analysis
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