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KMID : 1148920140480020091
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Nuclear Medicine and Molecular Imaging
2014 Volume.48 No. 2 p.91 ~ p.97
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Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma
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Kim Sung-Eun
Chung June-Key
Min Hae-Sook
Kang Joo-Hyun
Park Do-Joon
Jeong Jae-Min
Lee Dong-Soo
Park Sung-Hwae
Cho Bo-Youn
Lee Sin-Ae
Lee Myung-Chul
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Abstract
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Purpose: The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades.
Materials and Methods: Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n?=?13) and relatively less differentiated group (n?=?11).
Results: Glut-1 gene expression was significantly higher in the less differentiated group (0.66?±?0.04) than in the well-differentiated group (0.59?±?0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67?±?0.20, PD: 0.65?±?0.21, TG: 0.74?±?0.16) than in the less differentiated group (NIS: 0.36?±?0.05, PD: 0.49?±?0.08, TG: 0.60?±?0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD.
Conclusion: The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy.
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KEYWORD
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Glucose transporter-1, Sodium/iodide symporter, Thyroid peroxidase, Thyroglobulin, TSH receptor, Pendrin, Papillary thyroid cancer
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