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KMID : 1148920150490020108
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Nuclear Medicine and Molecular Imaging
2015 Volume.49 No. 2 p.108 ~ p.114
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Correlation Analysis and Prognostic Impact of 18F-FDG PET and Excision Repair Cross-Complementation Group 1 (ERCC-1) Expression in Non-Small Cell Lung Cancer
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Jeong Yong-Hyu
Lee Choong-Kun
Jo Kwan-Hyeong
Hwang Sang-Hyun
Cha Jong-Tae
Yun Mi-Jin
Cho Arthur
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Abstract
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Purpose: The aim of this study was to determine the relationship between [18]-2-fluoro-2-deoxy-D-glucose (FDG) uptake and excision repair cross-complementation group 1 (ERCC-1) expression and to evaluate the prognostic effect of these two factors in resectable non-small cell lung cancer (NSCLC) patients.
Methods: We retrospectively reviewed 212 patients with resectable NSCLC who underwent FDG positron emission tomography/computed tomography (PET/CT) scan for cancer staging and ERCC-1 expression analysis between January 2008 to December 2011. All patients were then followed-up for survival analysis. Semiquantitative evaluation of ERCC-1 was performed with the H-scoring system and was correlated with maximum standardized uptake value (SUVmax) of NSCLC. Univariate and multivariate analyses were performed to evaluate for FDG uptake and ERCC-1 expression predicting overall survival.
Results: In 212 patients (139 male, median age 68?±?9.11), 112 patients had ERCC-positive tumors and 100 patients had ERCC-negative tumors. There was no significant difference in SUVmax between ERCC-1-positive tumors (8.02?±?5.40) and ERCC-1-negative tumors (7.57?±?6.56, p?=?0.584). All patients were followed-up for a median of 40.5 months (95 % confidence interval [CI], 38.5?42.2 months). Univariate analysis and multivariate analysis for all patients showed that both ERCC-1 expression (hazard ratio [HR], 2.78; 95 % CI, 1.20?6.47) and FDG uptake (HR, 4.50; 95 % CI, 2.07?9.77) independently predicted overall survival.
Conclusions: We have found no statistical correlation between FDG uptake and ERCC-1 expression in NSCLC. However, both higher FDG uptake and positive ERCC-1 expression are independent predictive markers of prognosis, suggesting that both should be obtained during patient workup.
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KEYWORD
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FDG, PET/CT, ERCC, NSCLC, Prognosis
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