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KMID : 1148920150490040298
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Nuclear Medicine and Molecular Imaging
2015 Volume.49 No. 4 p.298 ~ p.302
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The Utility of Segmental Analysis in Cardiac I-123 MIBG SPECT in Parkinson’s Disease
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Kwon Soo-Hyun
Yoon Joon-Kee
Yoon Jung-Han
Lee Su-Jin
Jo Kyung-Sook
Lee Dong-Hyun
An Young-Sil
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Abstract
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Purpose: Cardiac images using I-123 metaiodobenzylguanidine (MIBG) are widely used to evaluate cardiac sympathetic denervation in Parkinson’s disease (PD). The aim of this study was to evaluate the utility of segmental analysis on cardiac MIBG SPECT in PD patients.
Materials and Methods: In total, 36 patients with PD (n?=?26) or essential tremor (ET, n?=?10) who underwent MIBG cardiac SPECT were enrolled. The heart-to-mediastinum (H/M) ratios of MIBG uptake were acquired on planar images. For the segmental analysis of SPECT images, we evaluated the summed defect score (SDS) using a 17-segment model. The diagnostic abilities of H/M ratios and segmental parameters on MIBG SPECT were assessed by ROC curve analysis.
Results: The H/M ratios were significantly lower in PD than in ET patients (p?
Conclusions: Segmental parameters from cardiac MIBG SPECT images can provide additional information to differentiate PD from ET patients. Beyond H/M ratios from planar images, we recommend an MIBG SPECT study to evaluate sympathetic denervation in PD.
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KEYWORD
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I-123 MIBG, Heart, SPECT, Parkinson’s disease, Segmental analysis
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