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KMID : 1148920160500010024
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 1 p.24 ~ p.30
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Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer
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Park So-Yeon
Lee Eun-Sub
Rhee Seung-Hong
Cho Jae-Hyuk
Choi Sun-Ju
Lee Sin-Ae
Eo Jae-Seon
Pahk Ki-Soo
Choe Jae-Gol
Kim Sung-Eun
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Abstract
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Purpose: The aim of this study was to evaluate the relationship between semiquantitative parameters on 18F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC).
Methods: Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18F-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining.
Results: Significant correlations were found between the MTVsum and Ki-67 labeling index (r?=?0.254, p?=?0.014) and the TLGtotal and Ki-67 labeling index (r?=?0.239, p?=?0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r?=?0.116, p?=?0.264) and the avgSUVmean and Ki-67 labeling index (r?=?0.031, p?=?0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p?=?0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p?=?0.526 and 0.729, respectively).
Conclusion: In conclusion, the volume-based parameters of 18F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.
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KEYWORD
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Small-cell lung carcinoma, 18F-FDG PET/CT, Metabolic tumor volume, Ki-67
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