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KMID : 1148920160500010031
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 1 p.31 ~ p.37
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Granulomatous Prostatitis After Intravesical Bacillus Calmette-Guerin Instillation Therapy: A Potential Cause of Incidental F-18 FDG Uptake in the Prostate Gland on F-18 FDG PET/CT in Patients with Bladder Cancer
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Kim Choon-Young
Lee Sang-Woo
Choi Seock-Hwan
Son Seung-Hyun
Jung Ji-Hoon
Lee Chang-Hee
Jeong Shin-Young
Ahn Byeong-Cheol
Lee Jae-Tae
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Abstract
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Purpose: This study aimed to evaluate the possibility that Bacillus Calmette-Guerin (BCG)-induced granulomatous prostatitis can be a potential cause of benign F-18 FDG uptake.
Methods: A total of 395 bladder cancer patients who underwent F-18 FDG PET/CT (PET/CT) were retrospectively evaluated. Patients were divided into two groups according to BCG therapy status. Elapsed time after BCG therapy, serum PSA level, results of prostate biopsy, and the SUVmax and uptake pattern in the prostate gland were reviewed. For patients who underwent follow-up PET/CT, the changes in SUVmax were calculated.
Results: While 35 % of patients showed prostate uptake in the BCG therapy group, only 1 % showed prostate uptake in the non-BCG therapy group (p?
Conclusions: BCG-induced granulomatous prostatitis can be a potential cause of benign F-18 FDG uptake, especially in those with a history of bladder cancer treated with BCG. In BCG-induced granulomatous prostatitis, focal or multifocal prostate uptake is frequently seen within 1 year after BCG therapy, and the intensity of prostate uptake is decreased on the follow-up PET/CT without any treatment.
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KEYWORD
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Bladder cancer, Intravesical BCG therapy, F-18 FDG PET/CT, Granulomatous prostatitis
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