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KMID : 1148920160500010070
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 1 p.70 ~ p.75
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Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [18F]FP-CIT PET Imaging Pilot Study
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Park Eun-Kyung
Hwang Yu-Mi
Chu Min-Kyung
Jung Ki-Young
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Abstract
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Purpose: Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([18F]FP-CIT) positron emission tomography (PET).
Methods: Brain [18F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BPND) of [18F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters.
Results: BPND at the brainstem was significantly higher in adult migraineurs (n?=?6, 1.15?±?0.17) than healthy subjects (0.95?±?0.14) (p?=?0.04). Healthy subjects demonstrated negative correlation between brainstem BPND and age (r?=??0.64, p?=?0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BPND (r?=?0.66, p?=?0.02), when age and duration of illness were corrected.
Conclusions: Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [18F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.
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KEYWORD
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Migraine, Serotonin transporter, [18F]FP-CIT, Positron emission tomography, Brainstem
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