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KMID : 1148920160500020112
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 2 p.112 ~ p.122
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Instrumentation for Time-of-Flight Positron Emission Tomography
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Ullah Muhammad Nasir
Pratiwi Eva
Cheon Ji-Min
Choi Ho-Jong
Yeom Jung-Yeol
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Abstract
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Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient’s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.
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KEYWORD
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Positron emission tomography, Time of flight, Instrumentation, Timing resolution
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