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KMID : 1148920160500030185
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 3 p.185 ~ p.195
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Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents
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Kim Dong-Yeon
Min Jung-Joon
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Abstract
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Despite substantial advances in the diagnosis of cardiovascular disease, 18F-labeled positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose heart disease because clinical use of current PET tracers is limited by their short half-life. Lipophilic cations such as phosphonium salts penetrate the mitochondrial membranes and accumulate in mitochondria of cardiomyocytes in response to negative inner-transmembrane potentials. Radiolabeled tetraphenylphosphonium cation derivatives have been developed as myocardial imaging agents for PET. In this review, a general overview of these radiotracers, including their radiosynthesis, in vivo characterization, and evaluation is provided and clinical perspectives are discussed.
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KEYWORD
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18F-Fluoroalkylphosphonium cations, Mitochondrial voltage sensors, Myocardial imaging agents, Positron emission tomography, Tetraphenylphosphonium cation derivatives
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