|
KMID : 1148920170510030227
|
|
Nuclear Medicine and Molecular Imaging
2017 Volume.51 No. 3 p.227 ~ p.232
|
|
|
Quantification of Contraction Synchronicity and Contraction Work in Coronary Artery Disease
|
|
Niimi Takanaga
Nanasato Mamoru
Maeda Hisatoshi
|
|
|
Abstract
|
|
|
Purpose: This study quantified the contraction synchronicity (CS; with 100% representing full synchrony and ?100% dyssynchrony) and contraction work (CW, millijoules per centimeter squared; representing myocardial area) in patients with reduced left ventricular ejection fraction (LVEF) associated with coronary artery disease (CAD).
Methods: CS, CW and LVEF in 104 subjects (54 CAD patients and 50 control subjects without CAD) were measured using rest electrocardiography-gated single-photon emission computed tomography (ECG SPECT). Contraction amplitude (CA), synchronous contraction index (SCI), and CW were evaluated using the program Quantification of Segmental Function by Solving the Poisson Equation (QSFP) developed in-house.
Results: The mean CA, SCI and CW of 17 segments in the control subjects were 33.8?±?4.1% (±SD), 96.6?±?1.4%, and 6.9?±?1.0 mJ/cm2, respectively. In the patients with CAD, the respective values were 26.1?±?7.3%, 82.1?±?16.8%, and 5.4?±?1.6 mJ/cm2. In the CAD patients with LVEF <40% (n?=?14), the mean CA, SCI,and CW were 17.9?±?4.0%, 63.0?±?18.4%, and 3.5?±?1.1 mJ/cm2, respectively. These values were significantly lower than in the control subjects (p?
Conclusion: Asynchrony shown using the QSFP is useful for CAD detection.
|
|
|
KEYWORD
|
|
|
Contraction amplitude, Contraction synchronicity, Contraction work, Left ventricular ejection fraction, Coronary artery disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|