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KMID : 1148920170510030233
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Nuclear Medicine and Molecular Imaging
2017 Volume.51 No. 3 p.233 ~ p.239
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Prognostic Value of Tumor-to-Blood Standardized Uptake Ratio in Patients with Resectable Non-Small-Cell Lung Cancer
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Shin Seung-Hyeon
Pak Kyoung-June
Kim In-Joo
Kim Bum-Soo
Kim Seong-Jang
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Abstract
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Objectives: Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUVmax). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery.
Methods: Seventy-seven patients who underwent curative resection for NSCLC between January 2010 to December 2013 were enrolled in this study. 18Fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) was performed before surgery. The mean standardized uptake value (SUVmean), SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of each lesion was measured, on the workstation. SURmean, SURmax, and TLGSUR were calculated by dividing each of them by descending aorta SUVmean. Cox proportional hazards regression was used to analyze the effect of age, sex, pathological parameters, and PET parameters on recurrence and death.
Results: In Cox regression analysis, N stage predicted for both recurrence (p?
Conclusions: Among PET parameters, SURmax was the independent predictor of recurrence in NSCLC patients who received curative surgery. N stage was the independent prognostic factor for both recurrence and death. Both parameters could be used to stratify the risk of NSCLC patients.
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KEYWORD
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Fluorodeoxyglucose F18, Positron-emission tomography, Prognosis, Non-small-cell lung cancer, Recurrence, Survival
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