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KMID : 1148920180520010074
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Nuclear Medicine and Molecular Imaging
2018 Volume.52 No. 1 p.74 ~ p.79
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Systemic Lupus Erythematosus Associated Pitfalls on 18F-FDG PET/CT: Reactive Follicular Hyperplasia, Kikuchi-Fujimoto Disease, Inflammation and Lymphoid Hyperplasia of the Spleen Mimicking Lymphoma
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Makis William
Ciarallo Anthony
Gonzalez-Verdecia Milene
Probst Stephan
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Abstract
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Systemic lupus erythematosus (SLE) is associated with a variety of inflammatory processes that can affect the lymph nodes, brain, kidneys, and spleen. We present two patients with SLE in whom SLE-associated conditions complicated interpretation of 18F-fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging of the lymph nodes and the spleen. The imaging findings mimicked lymphoma, but histopathological evaluation showed benign processes including reactive follicular hyperplasia in the lymph nodes, Kikuchi-Fujimoto disease in perisplenic lymph nodes, and inflammatory changes and lymphoid hyperplasia in the spleen.
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KEYWORD
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Systemic lupus erythematosus, SLE, Lymphoma, Kikuchi-Fujimoto disease, Spleen, PET/CT
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