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KMID : 1148920180520030224
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Nuclear Medicine and Molecular Imaging
2018 Volume.52 No. 3 p.224 ~ p.228
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A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195
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Ota Miho
Ogura Jun
Ogawa Shintaro
Kato Koichi
Matsuda Hiroshi
Kunugi Hiroshi
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Abstract
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Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.
Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined.
Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.
Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
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KEYWORD
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[11C]PK11195, Glial cells, Lipopolysaccharides, Positron emission tomography, Somatosensory area
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