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KMID : 1148920180520040279
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Nuclear Medicine and Molecular Imaging
2018 Volume.52 No. 4 p.279 ~ p.286
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Measurement of 68Ga-DOTATOC Uptake in the Thoracic Aorta and Its Correlation with Cardiovascular Risk
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Lee Ree-Ree
Kim Ji-Hyun
Paeng Jin-Chul
Byun Jung-Woo
Cheon Gi-Jeong
Lee Dong-Soo
Chung June-Key
Kang Keon-Wook
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Abstract
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Purpose: 68Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N′,N″,N?-tetraacetic acid-d-Phe1-Tyr3-octreotide (68Ga-DOTATOC) is taken up by activated macrophages, which accumulate in active inflammatory lesions. The purpose of this study was to investigate the feasibility of 68Ga-DOTATOC PET/CT for assessment of vulnerable plaque, by evaluating correlation between aortic uptake of 68Ga-DOTATOC and cardiovascular risk factors.
Methods: Fifty patients with neuroendocrine tumors who underwent 68Ga-DOTATOC PET/CT were retrospectively enrolled. The uptakes in the thoracic aorta were measured by two methods: multi-sample region-of-interest (ROI) method and single volume-of-interest (VOI) method. TBRmax-avg, TBRmean-avg, TBRmax-VOI, and TBRmean-VOI were defined by maximum and mean target-to-background ratio (TBR) from the multi-sample ROI method and the single VOI method, respectively.
Results: Framingham risk score (FRS) exhibited significant correlations with TBRmax-avg and TBRmean-avg, as well as TBRmax-VOI (r?=?0.3389?0.4593, P?
Conclusions: 68Ga-DOTATOC uptake in the thoracic aorta exhibited a significant correlation with cardiovascular risk factors, which suggests the feasibility of 68Ga-DOTATOC PET for vulnerable plaque imaging, with a simple measurement of the single VOI method that is comparable to the multi-sample ROI-based approach.
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KEYWORD
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PET/CT, Atherosclerosis, 68Ga-DOTATOC, Cardiovascular risk
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