Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 1148920180520060453
Nuclear Medicine and Molecular Imaging
2018 Volume.52 No. 6 p.453 ~ p.461
Predictive Value of Preoperative Volume-Based 18F-2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography/Computed Tomography Parameters in Patients with Resectable Lung Adenocarcinoma
Choi Sun-Ju

Kwon Hye-Ryeong
Cho Hee-Young
Pahk Ki-Soo
Lee Sung-Ho
Chung Jae-Ho
Kwon Hyun-Woo
Kim Sung-Eun
Abstract
Purpose: This study aimed to investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), which are volume-based PET parameters, using 18F-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with surgically resectable lung adenocarcinoma.

Methods: We retrospectively evaluated 149 patients with lung adenocarcinoma who underwent 18F-FDG PET/CT before surgical resection. Maximum standardized uptake value (SUVmax), MTV, and TLG of the primary tumor with threshold value of SUVmax 30, 40, and 50% were calculated, respectively. To compare the predictive performance of volume-based PET parameters, recurrence-free survival was assessed using the Kaplan-Meier method.

Results: The study included 70 males and 79 females with an average age of 65.8 years. The median follow-up time was 45.4 months. Recurrence was observed in 53 patients (35.6%). The mean?¡¾?SD SUVmax, MTV30%, and TLG30% of the entire cohort were 4.79?¡¾?2.94, 19.45?¡¾?24.85, and 56.43?¡¾?101.88, respectively. The cut-off values of MTV30% and TLG30% for recurrence were 11.07 ad 30.56, respectively. The 1-year recurrence-free survival (RFS) rate was 96.5% in low-MTV30% patients compared with 86.2% in high-MTV30% patients (p?=?0.018) and 96.0% in low-TLG30% patients compared with 88.5% in high-TLG30% patients (p?
Conclusion: TLG30% value was observed to be a significant prognostic factor for RFS in patients with lung adenocarcinoma treated by surgical resection.
KEYWORD
Lung adenocarcinoma, FDG PET/CT, Recurrence, Metabolic tumor volume, Total lesion glycolysis
FullTexts / Linksout information
Listed journal information
ÇмúÁøÈïÀç´Ü(KCI) KoreaMed ´ëÇÑÀÇÇÐȸ ȸ¿ø