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KMID : 1148920190530030182
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Nuclear Medicine and Molecular Imaging
2019 Volume.53 No. 3 p.182 ~ p.188
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Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals
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Seo Young-Ho
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Abstract
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Targeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-223, Ac-225, and Th-227) with relevance to imageable signals is attempted in this mini-review article. Gamma camera imaging, single-photon emission computed tomography, positron emission tomography, bremsstrahlung radiation imaging, Cerenkov luminescence imaging, and Compton cameras are briefly discussed as modalities for imaging alpha-emitting radiopharmaceuticals.
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KEYWORD
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Targeted alpha therapy, Quantitative imaging, SPECT, PET, Alpha-emitting radionuclide, Compton camera
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