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KMID : 1148920190530040247
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Nuclear Medicine and Molecular Imaging
2019 Volume.53 No. 4 p.247 ~ p.252
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Treatment Response Assessment of Skeletal Metastases in Prostate Cancer with 18F-NaF PET/CT
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Velez Erik M.
Desai Bhushan
Jadvar Hossein
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Abstract
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Purpose: To determine the utility of 18F-sodium fluoride positron emission tomography-computed tomography (18F-NaF PET/CT) in the imaging assessment of therapy response in men with osseous-only metastatic prostate cancer.
Methods: In this Institutional Review Board?approved single institution retrospective investigation, we evaluated 21 18F-NaF PET/CT scans performed in 14 patients with osseous metastatic disease from prostate cancer and no evidence of locally recurrent or soft-tissue metastatic disease who received chemohormonal therapy. Imaging-based qualitative and semi-quantitative parameters were defined and compared with changes in serum PSA level.
Results: Qualitative and semi-quantitative image-based assessments demonstrated >?80% concordance with good correlation (SUVmax κ?=?0.71, SUVavg κ?=?0.62, SUVsum κ?=?0.62). Moderate correlation (κ?=?0.43) was found between SUVmax and PSA-based treatment response assessments. There was no statistically significant correlation between PSA-based disease progression and semi-quantitative parameters. Qualitative imaging assessment was moderately correlated (κ?=?0.52) with PSA in distinguishing responders and non-responders.
Conclusion: 18F-NaF PET/CT is complementary to biochemical monitoring in patients with bone-only metastases from prostate cancer which can be helpful in subsequent treatment management decisions.
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KEYWORD
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18F-NaF, PET/CT, Prostate, Cancer, Metastasis, Bone
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