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KMID : 1148920200540010048
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Nuclear Medicine and Molecular Imaging
2020 Volume.54 No. 1 p.48 ~ p.52
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Role of 68Ga-DOTATATE PET/CT in a Case of SDHB-Related Pterygopalatine Fossa Paraganglioma Successfully Controlled with Octreotide
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Jha Abhishek
Patel Mayank
Baker Eva
Gonzales Melissa K.
Ling Alexander
Millo Corina M.
Knue Marianne
Civelek Ali Cahid
Pacak Karel
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Abstract
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We describe an unusual case of a 42-year-old female with an unresectable succinate dehydrogenase subunit B (SDHB)-related pterygopalatine fossa paraganglioma. She underwent somatostatin receptor imaging with 68Ga-DOTA(0)-Tyr(3)-octreotate (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT), which showed uptake in the above mentioned tumor. Hence, the patient was started on octreotide, a cold somatostatin analog, and responded with tumor stabilization and improvement of clinical symptoms for 36 months since initiation of octreotide therapy. This case demonstrates the role of 68Ga-DOTATATE PET/CT in diagnostic localization and its subsequent role in treatment using cold somatostatin analog as a potential choice of therapy in the management of paraganglioma in an unusual location with limited therapeutic options.
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KEYWORD
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68Ga-DOTATATE PET/CT, Paraganglioma, Octreotide, SDHB, SSTR, Somatostatin analog, PRRT, 177Lu-DOTATATE
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