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KMID : 1148920200540060281
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Nuclear Medicine and Molecular Imaging
2020 Volume.54 No. 6 p.281 ~ p.291
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Comparison of 18F-NaF PET/CT with Other Imaging Methods in the Detection of Bone Metastases in Patients with Medullary Thyroid Cancer: a Report of a Series of 31 Cases
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Ueda Cristina Emiko
Duarte Paulo Schiavom
de Castroneves Luciana Audi
Coura-Filho George Barberio
Sado Heitor Naoki
Sapienza Marcelo Tatit
Hoff Ana Oliveira
Buchpiguel Carlos Alberto
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Abstract
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Purpose: To compare the 18F-NaF PET/CT studies (18F-NaF) with other imaging methods in the detection of skeletal metastases (SM) in patients with medullary thyroid cancer (MTC).
Methods: We retrospectively analyzed 31 patients with MTC who performed 18F-NaF to assess SM. The results of the 18F-NaF were compared with other imaging methods performed for metastasis detection: 99Tc-MDP bone scan (BS), magnetic resonance imaging (MRI), contrast-enhanced CT (CT), and 68Ga-Dotatate and 18F-FDG PET/CT studies. A qualitative analysis comparing the 18F-NaF findings with the ones of the other methods was performed, and the results were classified as superior (>), equal (=), and inferior (<).
Results: Eleven patients had no bone metastases detected on any of the imaging methods used. Twenty patients presented SM depicted on 18F-NaF. Of these 20 patients, 12 performed bone scan (in 9 18F-NaF?>?BS and in 3 18F-NaF?=?BS), 1 performed 18F-FDG (18F-NaF?>?18F-FDG), 4 performed 68Ga-Dotatate (in 2 18F-NaF?>?68Ga-Dotatate and in 2 18F-NaF?=?68Ga-Dotatate), 20 performed CT of at least one body segment (in 15 18F-NaF = CT and in 5 18F-NaF?>?CT), and 16 performed MRI of at least one body segment, and in all of them, the 18F-NaF was equal to the MRI. Beside this, the 18F-NaF detected SM in body segments not routinely scanned in MRI and CT.
Conclusion: In patients with MTC, the 18F-NaF seems to be equal or superior to other imaging modalities in the detection of SM and allows the analysis of the whole skeletal in a single study.
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KEYWORD
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Fluorine, 18F, PET/CT, 18F-NaF, Medullary thyroid carcinoma, Bone metastases
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