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KMID : 1148920220560010029
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Nuclear Medicine and Molecular Imaging
2022 Volume.56 No. 1 p.29 ~ p.41
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Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19
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Kiatkittikul Peerapon
Promteangtrong Chetsadaporn
Kunawudhi Anchisa
Siripongsatian Dheeratama
Siripongboonsitti Taweegrit
Ruckpanich Piyanuj
Thongdonpua Supachoke
Jantarato Attapon
Piboonvorawong Chaiyawat
Fonghoi Nirawan
Chotipanich Chanisa
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Abstract
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Purpose: The study aimed to investigate imaging abnormalities associated with post-acute COVID-19 using F-18 FDG PET/CT and PET/ rsfMRI brain.
Methods: We retrospectively recruited 13 patients with post-acute COVID-19. The post-acute COVID-19 symptoms and neuropsychiatric tests were performed before F-18 FDG PET/CT whole body with PET/rsfMRI brain. Qualitative and semiquantitative analyses were also conducted in both whole body and brain images.
Results: Among the 13 patients, 8 (61.5%) had myositis, followed by 8 (61.5%) with vasculitis (mainly in the thoracic aorta), and 7 (53.8%) with lung abnormalities.. Interestingly, one patient with a very high serum RBD IgG antibody demonstrated diffuse myositis throughout the body which potentially associated with immune-mediated myositis. One patient experienced psoriasis exacerbation with autoimmune-mediated after COVID-19. Most patients had multiple areas of abnormal brain connectivity involving the frontal and parieto-temporo-occipital lobes, as well as the thalamus.
Conclusion: The whole body F-18 FDG PET can be a potential tool to assess inflammatory process and support the hyperinflammatory etiology, mainly for lesions in skeletal muscle, vascular wall, and lung, as well as, multiple brain abnormalities in post-acute COVID-19. Nonetheless, further studies are recommended to confirm the results.
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KEYWORD
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Post-acute COVID-19, Long COVID-19, Inflammation, F-18 FDG PET, Fluorodeoxyglucose, Resting-state functional MRI
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