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KMID : 1148920220560010052
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Nuclear Medicine and Molecular Imaging
2022 Volume.56 No. 1 p.52 ~ p.58
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A Negative Correlation Between Blood Glucose Level and 68 Ga-DOTA-TOC Uptake in the Pancreas Uncinate Process
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Oh Dong-Kyu
Choi Hong-Yoon
Paeng Jin-Chul
Kang Keon-Wook
Cheon Gi-Jeong
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Abstract
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Purpose: 68 Ga-DOTA-TOC uptake in the pancreas uncinate process is often found due to physiologic expression of somatostatin receptors (SSTR). We investigated the association of physiologic 68 Ga-DOTA-TOC uptake in the pancreas uncinate process with blood glucose level.
Methods: 68 Ga-DOTA-TOC PET scans acquired from 44 patients (male:female?=?20:24, age?=?50.8?±?14.8y [mean?±?SD]) were retrospectively analyzed. The blood glucose level (BGL) was examined before 68 Ga-DOTA-TOC injection. Patients diagnosed with diabetes mellitus and patients with BGL over 200 mg/dl were excluded. 68 Ga-DOTA-TOC uptake was measured by the maximum standardized uptake values (SUVmax). Additionally, SSTR-positive volume (SV) in the pancreas uncinate process was measured with two different thresholds: by SUV cutoff of 2.5 (SV2.5) and 40% of SUVmax (SV40%). These measurements on 68 Ga-DOTA-TOC PET were correlated with BGL.
Results: The mean of SUVmax of the pancreas uncinate process was 6.51?±?2.04. SV2.5 was 17.81?±?7.14 cm3, and SV40% was 18.20?±?8.83 cm3. A significant negative correlation was found between SUVmax of the pancreas uncinate process and BGL (r?=?-0.37, p?=?0.01). The ratio between SUVmax of the pancreas uncinate process and SUVmean of the pancreas body also showed a significance negative correlation with BGL (r?=?-0.40, p?=?0.01). SV2.5 (r?=?0.27, p?=?0.07) and SV40% (r?=?-0.151, p?=?0.32) were not significantly correlated with BGL.
Conclusion: Physiologic 68 Ga-DOTA-TOC uptake in the pancreas uncinate process was negatively correlated with BGL. Our results suggested that glycemia could affect physiologic uptake of 68 Ga-DOTA-TOC.
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KEYWORD
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68 Ga-DOTA-TOC, PET, Uncinate, Pancreatic polypeptide cell, Blood glucose level
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