Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 1148920220560030158
Nuclear Medicine and Molecular Imaging
2022 Volume.56 No. 3 p.158 ~ p.168
Relationship Between Vitamin D Status and Brain Perfusion in Neuropsychiatric Lupus
Sultana Nasreen

Sarkar Azmal Kabir
Matsuda Hiroshi
Ihsan Md Amimul
Haq Syed Atiqul
Arefin Md Saidul
Islam Sheikh Nazrul
Abstract
Purpose: Neuropsychiatric manifestation of lupus (NPSLE) is related with vitamin D (vit-D) deficiency which is possibly amenable to supplementation. This study was done to explore link of serum vit-D level and clinical mini-mental state examination (MMSE) with brain perfusion SPECT (BS) in patients with NPSLE.

Methods: Patients who underwent BS with the diagnosis of NPSLE and had serum levels of vit-D and MMSE within a span of 1 month were retrospectively included. The BS DICOM data were used to generate 3D surface images of brain for visual identification of regional hypoperfusion, and the z-scores from eZIS software and then to perform voxel-based regression analysis in order to explore association between serum vit-D level and cerebral perfusion deficit using SPM8. Distribution of serum vit-D level was checked across MMSE and BS z-score using R.

Results: A total 19 patients with means ¡¾ SD age of 28.4 ¡¾ 9.2 years, having mean levels of serum vit-D of 18.7 ¡¾ 9.8 ng/ml and mean MMSE scores 24.2 ¡¾ 1.6, had undergone BS. The eZIS-derived z-score fall in the category of normal in six (31.6%), mild perfusion deficit (PD) in 10 (52.6%) and moderate PD in three (15.8%) with the means ¡¾ SD of z-score being 0.52 ¡¾ 0.2, 1.72 ¡¾ 0.2, and 2.33 ¡¾ 0.2. Voxel-based analysis revealed significant positive correlation between vit-D level and hypoperfusion in brain regions related to cognitive function (p<0.05). Serum vit-D levels were significantly lower in NPSLE patients with lower MMSE scores as well as in higher eZIS z-score (p < 0.01).

Conclusions: Our results may support the utility of vit-D supplementation in NPSLE and applicability of BS as a clinical adjunct for monitoring response to vit-D supplementation.
KEYWORD
Neuropsychiatric systemic lupus erythematosus, Brain, SPECT, Voxel-based analysis, Statistical parametric mapping, Vitamin D deficiency, Cognitive function
FullTexts / Linksout information
Listed journal information
ÇмúÁøÈïÀç´Ü(KCI) KoreaMed ´ëÇÑÀÇÇÐȸ ȸ¿ø