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KMID : 1156220060320020192
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Journal of Environmental Health Sciences
2006 Volume.32 No. 2 p.192 ~ p.197
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Anti-microbial Activity of Soybean Extract Against Oral Microbes
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Lee Sung-Lym
Kim Jong-Gyu
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Abstract
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This study was performed to investigate anti-microbial activity of soybean extract against oral microbes, and to determine the minimum inhibition concentration (MIC) for microbes causing oral diseases. The soybean extract was prepared using ethyl acetate and it was treated with 16 types of oral microbes at a concentration of 5.00 ㎎/㎖ (0.5%). The MIC of soybean extract for three major microbes causing oral diseases was determined. The anti-microbial activity and MIC were measured using broth dilution method. Significant reduction of microbial activities of 9 types oral microbes when the soybean extract was added to the broth compared to the control (p＜0.01). The extract showed higher anti-microbial activity against some anaerobic strains (P. gingivalis and P. intermedia). S. mutans, which causes dental caries, showed MIC at a concentration of 40 ㎎/㎖ for the soybean extract. P. gingivalis, which causes adult periodontal disease, showed MIC at a concentration of 20 ㎎/㎖ for the extract. C. albicans, which causes denture stomatitis and angular stomatitis, showed MIC at a concentration of 20 ㎎/㎖ for the extract. These results indicate that soybean extract showed anti-microbial effect against 9 types of oral microbes, and the anti-microbial effect of the extract against oral microbes was stronger against fungi than against bacteria. The anti-microbial mechanism of soybean extract against oral microbes should be investigated, and more research for clinical application is required at a level of actual intake.
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KEYWORD
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soybean extract, anti-microbial activity, oral microbes
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